第四季开始，艾美奖得主Uzo Aduba饰演新主角，治疗专家Brooke Taylor医生。她将在诊疗中面对多元化的三位病人，与此同时也在与自己的问题作斗争。 Joel Kinnaman将饰演Adam。他是主角医生Brooke时分时合的男友，现在再次出现，让Brooke的生活变得更加复杂。 Anthony Ramos饰演Eladio，病人之一。他是一个有钱人家里成年儿子的家庭护理。 Liza Colón-Zayas饰演Rita。她是Brooke结交已久的知心朋友，给了Brooke很多支持。但Rita在经历了一场改变人生的损失后，也在抗争着自己的心魔。 John Benjamin Hickey饰演Colin。原本是魅力十足的富豪，后来成了一名白领罪犯，最近刚出狱的他需要面对自己生活中方方面面的变化。 Quintessa Swindell饰演Laila。Brooke的客户之一，多疑又叛逆的一名青少年，竭力想要在家人的殷切期盼中找到属于自己的身份。
Hugo Llor, a 12-year-old boy who spends most of his time on the streets. His day is also spent in the shipyards and his dream is to become a shipbuilding craftsman, although his fate is uncertain. Hugo's life is not easy, he is a very lonely boy and his mother is forced to move away from him, but he has the support and protection of a respected old man: Arnau Estanyol.
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